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Article

Metabolism of steroids by cytochrome P450 2C9 variants.

Biopharmaceutics & drug disposition - 1 Sept 2018

Uno Tomohide, Nakano Ryosuke, Kitagawa Risa, Okada Mai, Kanamaru Kengo, Takenaka Shinji, Uno Yuichi, Imaishi Hiromasa

Abstract excerpt

CYP2C9 is a human microsomal cytochrome P450c (CYP). Much variation in CYP2C9 levels and activity can be attributed to polymorphisms of this gene. Wild-type CYP2C9 and ten mutants were co-expressed with NADPH-cytochrome P450 reductase in Escherichia coli. The hydroxylase activities toward steroids were examined. CYP2C9.2, CYP2C9.3, CYP2C9.4, CYP2C9.16, CYP2C9.28, CYP2C9.48 and CYP2C9.52 had higher testosterone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30098040
DOI: 10.1002/bdd.2153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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