Article
Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner.
Journal of molecular biology - 27 Jun 2008
Gomez-Duran Aurea, Ballestar Esteban, Carvajal-Gonzalez Jose M, Marlowe Jennifer L, Puga Alvaro, Esteller Manel, Fernandez-Salguero Pedro M
Abstract excerpt
Latent TGFbeta-binding protein 1 (LTBP-1) is a key regulator of TGFbeta targeting and activation in the extracellular matrix. LTBP-1 is recognized as a major docking molecule to localize, and possibly to activate, TGFbeta in the extracellular matrix. Despite this relevant function, the molecular...
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