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Article

Sirt1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription

29 Nov 2017

Abstract excerpt

BACKGROUND: The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses. This is often justified by the complex regulation showed by Smad proteins, TGFβ signaling intracellular transducers, object of post-translational modifications that modulate TGFβ-dependent transcription. Protein acetylation is emerging as a compelling mechanism...

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PMID: 29187201
DOI: 10.1186/s12964-017-0205-y

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