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Article

4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress.

The Journal of biological chemistry - 17 Aug 2007

Hughes Adam L, Lee Chih-Yung S, Bien Clara M, Espenshade Peter J

Abstract excerpt

In fission yeast, orthologs of mammalian SREBP and Scap, called Sre1 and Scp1, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply. Under low oxygen conditions, sterol synthesis is inhibited, and Sre1 cleavage is activated. However, the sterol signal for Sre1 activati...

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Identifiers

PMID: 17595166
DOI: 10.1074/jbc.M701326200
PMCID: PMC2262954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17595166-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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