Article
Association study of -1727 A/T, -50 C/T and (CAA)n repeat GSK-3beta gene polymorphisms with schizophrenia.
Neuropsychobiology - 1 Jan 2004
Scassellati Catia, Bonvicini Cristian, Perez Jorge, Bocchio-Chiavetto Luisella, Tura Gian Battista, Rossi Giuseppe, Racagni Giorgio, Gennarelli Massimo
Abstract excerpt
Glycogen synthase kinase-3 (GSK-3) is a downstream component of the Wnt pathway and recent studies have reported abnormal levels of GSK-3beta in schizophrenia. In a sample of 147 schizophrenic patients and 212 healthy individuals, we analyzed two common SNPs at position -1727 A/T and -50 C/T and a (CAA)(n) repeat polymorphism localized in intron 1 of the gene. The results showed that the allele, genotype and...
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