Article
Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae.
Molecular cell - 6 Jun 2013
Klug Helene, Xaver Martin, Chaugule Viduth K, Koidl Stefanie, Mittler Gerhard, Klein Franz, Pichler Andrea
Abstract excerpt
Posttranslational modification with the small ubiquitin-related modifier SUMO depends on the sequential activities of E1, E2, and E3 enzymes. While regulation by E3 ligases and SUMO proteases is well understood, current knowledge of E2 regulation is very limited. Here, we describe modification of the budding yeast E2 enzyme Ubc9 by sumoylation (Ubc9(*)SUMO). Although less than 1% of Ubc9 is sumoylated at Lys153...
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