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Article

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.

Molecular cell - 1 Apr 1999

Ohta T, Michel J J, Schottelius A J, Xiong Y

Abstract excerpt

We have identified two highly conserved RING finger proteins, ROC1 and ROC2, that are homologous to APC11, a subunit of the anaphase-promoting complex. ROC1 and ROC2 commonly interact with all cullins while APC11 specifically interacts with APC2, a cullin-related APC subunit. YeastROC1 encodes an essential gene whose reduced expression resulted in multiple, elongated buds and accumulation of Sic1p and Cln2p. ROC1...

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Share to Anaphase-Promoting Complex-Cyclosome
Share to Cullin Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to F-Box-WD Repeat-Containing Protein 7

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Source

Identifiers

PMID: 10230407
DOI: 10.1016/s1097-2765(00)80482-7

Genes

APC
APC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.PMID 10230407Read ↗

Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases.Semantic proximity Read ↗

Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization.Semantic proximity Read ↗

In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3.Semantic proximity Read ↗

Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase.Semantic proximity Read ↗

The functional analysis of Cullin 7 E3 ubiquitin ligases in cancerSemantic proximity Read ↗

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A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

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ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and SenescenceSemantic proximity Read ↗

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