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Article

Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.

Molecular biology of the cell - 1 Jul 2013

Flusberg Deborah A, Roux Jérémie, Spencer Sabrina L, Sorger Peter K

Abstract excerpt

When clonal populations of human cells are exposed to apoptosis-inducing agents, some cells die and others survive. This fractional killing arises not from mutation but from preexisting, stochastic differences in the levels and activities of proteins regulating apoptosis. Here we examine the properties of cells that survive treatment with agonists of two distinct death receptors, tumor necrosis factor-related...

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Identifiers

PMID: 23699397
DOI: 10.1091/mbc.E12-10-0737
PMCID: PMC3708725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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