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Article

Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death.

Journal of cell science - 15 Sept 2004

Li Jinquan, Li Qinxi, Xie Changchuan, Zhou Huamin, Wang Yuqian, Zhang Na, Shao Hanjuan, Chan Siu Chiu, Peng Xuanxian, Lin Sheng-Cai, Han Jiahuai

Abstract excerpt

Tumor necrosis factor (TNF)-alpha induces caspase-independent cell death in the fibrosarcoma cell line L929. This cell death has a necrotic phenotype and is dependent on production of reactive oxygen species (ROS) in the mitochondria. To identify genes involved in this TNF-induced, ROS-dependent cell death pathway, we utilized retrovirus insertion-mediated random mutagenesis to generate TNF-resistant L929 cell...

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PMID: 15371523
DOI: 10.1242/jcs.01339

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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