Article
Isolation and propagation of a human CD133(-) colon tumor-derived cell line with tumorigenic and angiogenic properties.
Cell transplantation - 1 Jan 2010
Navarro-Alvarez Nalú, Kondo Eisaku, Kawamoto Hironobu, Hassan Wael, Yuasa Takeshi, Kubota Yasuhiro, Seita Masayuki, Nakahara Hiroyuki, Hayashi Takahiro, Nishikawa Yuriko, Hassan Reham A R A, Javed Shahid M, Noguchi Hirofumi, Matsumoto Shinichi, Nakaji Shuhei, Tanaka Noriaki, Kobayashi Naoya, Soto-Gutierrez Alejandro
Abstract excerpt
It has been proposed in human colorectal cancers (CRC) a minority subset of cancer cells within tumors able to initiate tumor growth, defined as cancer stem cells (CSC). Solid human primary colonic and its ovarian metastatic cancer tissues were collected from fresh surgical samples and subsequent xenografts were established in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. The resulting tumors...
Topics
- AC133 Antigen
- Adult
- Animals
- Antigens, CD
- Biomarkers, Tumor
- Cell Line, Tumor
- Cell Proliferation
- Cell Separation
- Colonic Neoplasms