Article
Identification and expansion of human colon-cancer-initiating cells.
Nature - 4 Jan 2007
Ricci-Vitiani Lucia, Lombardi Dario G, Pilozzi Emanuela, Biffoni Mauro, Todaro Matilde, Peschle Cesare, De Maria Ruggero
Abstract excerpt
Colon carcinoma is the second most common cause of death from cancer. The isolation and characterization of tumorigenic colon cancer cells may help to devise novel diagnostic and therapeutic procedures. Although there is increasing evidence that a rare population of undifferentiated cells is responsible for tumour formation and maintenance, this has not been explored for colorectal cancer. Here, we show that...
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