Article
CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 2012
Chao Celia, Carmical J Russ, Ives Kirk L, Wood Thomas G, Aronson Judith F, Gomez Guillermo A, Djukom Clarisse D, Hellmich Mark R
Abstract excerpt
Experimental data indicate that colorectal cancer cells with CD133 expression exhibit enhanced tumorigenicity over CD133-negative (CD133-) cells. We hypothesized that CD133-positive (CD133+) cells, compared with CD133-, are more tumorigenic because they are more interactive with and responsive to their stromal microenvironment. Freshly dissected and dissociated cells from a primary colon cancer were separated...
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