Article
Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2009
Gonzalez-Angulo Ana M, Stemke-Hale Katherine, Palla Shana L, Carey Mark, Agarwal Roshan, Meric-Berstam Funda, Traina Tiffany A, Hudis Clifford, Hortobagyi Gabriel N, Gerald William L, Mills Gordon B, Hennessy Bryan T
Abstract excerpt
PURPOSE: To examine the androgen receptor (AR) levels in breast cancer and to assess the impact of AR expression on patient outcomes. EXPERIMENTAL DESIGN: Reverse-phase protein arrays were used to measure AR levels and a mass spectroscopy-based approach was used to detect PIK3CA mutations. Means and SDs were generated for AR levels. Linear regression models were used to determine if AR levels differed by tumor...
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