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Article

Estradiol rapidly activates Akt via the ErbB2 signaling pathway.

Molecular endocrinology (Baltimore, Md.) - 1 May 2003

Stoica Gerald E, Franke Thomas F, Wellstein Anton, Czubayko Frank, List Heinz-Joachim, Reiter Ronald, Morgan Elisha, Martin Mary Beth, Stoica Adriana

Abstract excerpt

Previously, we have demonstrated that the two mitogenic growth factors epidermal growth factor and IGF-I can activate Akt and estrogen receptor-alpha (ERalpha) in the hormone-dependent breast cancer cell line, MCF-7. In this report we now show that estradiol can also rapidly activate phosphatidylinositol 3-kinase (PI 3-K)/Akt and that this effect is mediated by the ErbB2 signaling pathway. Treatment of cells with...

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Identifiers

PMID: 12554767
DOI: 10.1210/me.2002-0330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Estradiol rapidly activates Akt via the ErbB2 signaling pathway.PMID 12554767Read ↗

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