Article
Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2005
Nelson-Degrave Velen L, Wickenheisser Jessica K, Hendricks Karen L, Asano Tomoichiro, Fujishiro Midori, Legro Richard S, Kimball Scot R, Strauss Jerome F, McAllister Jan M
Abstract excerpt
We have investigated the involvement of the MAPK signaling pathway in increased androgen biosynthesis and CYP17 gene expression in women with polycystic ovary syndrome (PCOS). A comparison of MAPK kinase (MEK1/2) and ERK1/2 phosphorylation in propagated normal and PCOS theca cells, revealed that...
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