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Article

Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.

Psychopharmacology - 1 Aug 2008

Jacobsen Jacob P R, Nielsen Elsebet Ø, Hummel Rene, Redrobe John Paul, Mirza Naheed, Weikop Pia

Abstract excerpt

RATIONALE: Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of antidepressant responses. OBJECTIVES: The objective of this study was to explore whether insensitivity to selective serotonin reuptake inhibitors (SSRIs) in NMRI mice in the tail suspension test can be related to 5-hydroxytryptamine (5-HT) function. MATERIALS...

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Source

Identifiers

PMID: 18496675
DOI: 10.1007/s00213-008-1142-7

Genes

HTT
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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