Article
Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice.
BMC developmental biology - 15 Mar 2006
Miller Leigh-Anne D, Smith April N, Taketo M Mark, Lang Richard A
Abstract excerpt
BACKGROUND: The canonical Wnt signaling pathway has a number of critical functions during embryonic development and, when activated aberrantly, in the genesis of cancer. Current evidence suggests that during eye development, regulation of Wnt signaling is critical for patterning the surface ectoderm that will contribute to multiple components of the eye. Wnt signaling loss-of-function experiments show that a...
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