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Article

dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity.

Developmental biology - 1 Jan 2009

Esterberg Robert, Fritz Andreas

Abstract excerpt

The vertebrate inner ear arises from the otic placode, a transient thickening of ectodermal epithelium adjacent to neural crest domains in the presumptive head. During late gastrulation, cells fated to comprise the inner ear are part of a domain in cranial ectoderm that contain precursors of all sensory placodes, termed the preplacodal region (PPR). The combination of low levels of BMP activity coupled with high...

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Identifiers

PMID: 19007769
DOI: 10.1016/j.ydbio.2008.10.017
PMCID: PMC2674874

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