Article
Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD).
Clinical and experimental immunology - 1 Mar 1996
Bouma G, Xia B, Crusius J B, Bioque G, Koutroubakis I, Von Blomberg B M, Meuwissen S G, Peña A S
Abstract excerpt
In 153 patients with IBD, 64 with Crohn's disease (CD), and 89 with ulcerative colitis (UC), as well as in 54 healthy controls (HC), the frequencies of four known di-allelic polymorphisms in the genes for TNF-alpha and lymphotoxin alpha (LTalpha) were investigated. In the Dutch population, the alleles of these four polymorphisms are present in only five combinations, called TNF haplotypes: TNF-C, -E, -H, -I, -P....
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