Article
HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations.
Human immunology - 1 Mar 2000
Trachtenberg E A, Yang H, Hayes E, Vinson M, Lin C, Targan S R, Tyan D, Erlich H, Rotter J I
Abstract excerpt
Ulcerative colitis (UC) and Crohn's disease (CD) are the clinical entities comprising idiopathic inflammatory bowel disease (IBD). Previous studies on the association of IBD and human leukocyte antigen (HLA) class II genes suggested a role for HLA in this disease. Here we present HLA class II (DRB1, DQB1, DQA1, DPB1) allele and haplotype distributions determined using the polymerase chain reaction and...
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