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Article

The human paraoxonase-1 phenotype modifies the effect of statins on paraoxonase activity and lipid parameters.

British journal of clinical pharmacology - 1 Sept 2008

Mirdamadi Hossein Z, Sztanek Ferenc, Derdak Zoltan, Seres Ildiko, Harangi Mariann, Paragh György

Abstract excerpt

AIMS: Human serum paraoxonase-1 (PON1) protects lipoproteins against oxidation by hydrolysing lipid peroxides in oxidized low-density lipoprotein, therefore it may protect against atherosclerosis. One of the two common PON1 gene polymorphisms within the PON1 gene is the Q192R, whose prevalence can be estimated by phenotype distribution analysis. The goal of this study was to clarify the role of PON1 phenotypes on...

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Source

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Identifiers

PMID: 18492126
DOI: 10.1111/j.1365-2125.2008.03213.x
PMCID: PMC2526235

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The human paraoxonase-1 phenotype modifies the effect of statins on paraoxonase activity and lipid parameters.PMID 18492126Read ↗

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