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Article

A prospective study to assess the role of paraoxonase 1 genotype and phenotype on the lipid-lowering and antioxidant activity of statins.

Indian journal of pharmacology - 1 Jan 2000

Godbole Charuta, Thaker Saket, Salagre Santosh, Shivane Vyankatesh, Gogtay Nithya, Thatte Urmila

Abstract excerpt

Human paraoxonase 1 (PON1) enzyme protects against atherosclerosis by preventing low-density lipoprotein from oxidative modification. Upregulation of PON1 enzymatic activity is suggested to contribute to atheroprotective potential of statins. Glutamine (Q) to arginine (R) at site 192 and leucine (L) to methionine (M) substitution at site 55 polymorphisms influence the PON1 activity. The study assessed the role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37555413
DOI: 10.4103/ijp.IJP_215_20
PMCID: PMC10501533

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