Article
MAX-rank: a simple and robust genome-wide scan for case-control association studies.
Human genetics - 1 Jul 2008
Li Qizhai, Yu Kai, Li Zhaohai, Zheng Gang
Abstract excerpt
In genome-wide association studies (GWAS), single-marker analysis is usually employed to identify the most significant single nucleotide polymorphisms (SNPs). The trend test has been proposed for analysis of case-control association. Three trend tests, optimal for the recessive, additive and dominant models respectively, are available. When the underlying genetic model is unknown, the maximum of the three trend...
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