Article
Use of max and min scores for trend tests for association when the genetic model is unknown.
Statistics in medicine - 30 Aug 2003
Zheng Gang
Abstract excerpt
In case-control studies, the Cochran-Armitage (CA) trend test is powerful for detection of an association between a risk allele and a marker. To apply this test, a score should be assigned to the genotypes based on the genetic model. When the underlying genetic model is unknown, the trend test statistic is a function of the score. In this paper, simple procedures are given to obtain two scores (max and min),...
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