Article

Gpr125 identifies myoepithelial progenitors at tips of lacrimal ducts and is essential for tear film

2020-09-16

Abstract excerpt

Gpr125, encoded by Adgra3 , is an orphan adhesion G-protein coupled receptor (aGPCR) implicated in modulating Wnt signaling and planar polarity. Here we establish both physiological and pathological roles for Gpr125. We show that mice lacking Gpr125 or its signaling domains display an ocular phenotype with many hallmarks of human dry eye syndrome. These include squinting, abnormal lacrimation, mucus accumulation,...

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Literature Corpus work: 31260f21-b563-5f5a-9f70-25f36abeb0ee
DOI: 10.1101/2020.09.15.296749

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