Article
Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor.
The Journal of biological chemistry - 5 Jun 1992
Yoshimura A, Zimmers T, Neumann D, Longmore G, Yoshimura Y, Lodish H F
Abstract excerpt
The erythropoietin receptor (EPOR) is a member of the newly identified cytokine receptor superfamily. A common sequence motif, Trp-Ser-X-Trp-Ser (WSXWS), near the transmembrane domain is highly conserved in this family. To determine the function of this motif, we constructed deletion and insertio...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cells, Cultured
- DNA
- Erythropoietin
- Interleukin-3
- Ligands
- Mice
- Microscopy, Fluorescence
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Processing, Post-Translational
- Receptors, Cell Surface
- Receptors, Erythropoietin