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Article

Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter.

Molecular and cellular biology - 1 Apr 1991

Bartholomew C, Ihle J N

Abstract excerpt

The inappropriate production of the Evi-1 zinc finger protein occurs in retrovirus-induced murine myeloid leukemias and human acute myelogenous leukemias. In murine leukemias, expression of the Evi-1 gene is associated with retroviral insertions either in the Evi-1 locus, which is immediately 5' of the coding region of the gene, or in the genetically linked Cb-1/fim-3 locus. In these studies, we demonstrate by...

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Identifiers

PMID: 1848663
DOI: 10.1128/mcb.11.4.1820-1828.1991
PMCID: PMC359852

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter.PMID 1848663Read ↗

Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26.Semantic proximity Read ↗

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemiaSemantic proximity Read ↗

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocationsSemantic proximity Read ↗

<i>Evi9</i> Encodes a Novel Zinc Finger Protein That Physically Interacts with BCL6, a Known Human B-Cell Proto-Oncogene ProductSemantic proximity Read ↗

Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies.Semantic proximity Read ↗

Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.Semantic proximity Read ↗

EVI1 dysregulation: impact on biology and therapy of myeloid malignancies.Semantic proximity Read ↗

Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemiaSemantic proximity Read ↗

A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF–induced myeloid differentiationSemantic proximity Read ↗

The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG.Semantic proximity Read ↗

[The role of SF3B1 mutations in EVI1-rearranged myeloid neoplasms].Semantic proximity Read ↗

Review: Aberrant <i><scp>EVI</scp>1</i> expression in acute myeloid leukaemiaSemantic proximity Read ↗

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