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Article

Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.

15 Jul 1993

Abstract excerpt

Inappropriate expression of the Evi-1 zinc-finger gene in hematopoietic cells has been associated with acute myelogenous leukemia and myelodysplastic syndromes in murine models and in humans. Consistent with this, previous studies have shown that aberrant expression of the Evi-1 gene in a myeloid progenitor cell line blocks granulocytic differentiation. Here we demonstrate that the aberrant expression of the...

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Identifiers

PMID: 8341654
DOI: 10.1073/pnas.90.14.6454

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.PMID 8341654Read ↗

Point Mutations in Two EVI1 Zn Fingers Abolish EVI1-GATA1 Interaction and Allow Erythroid Differentiation of Murine Bone Marrow CellsSemantic proximity Read ↗

The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG.Semantic proximity Read ↗

Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter.Semantic proximity Read ↗

EVI1 Impairs Myelopoiesis by Deregulation of PU.1 FunctionSemantic proximity Read ↗

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocationsSemantic proximity Read ↗

Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemiaSemantic proximity Read ↗

Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome.Semantic proximity Read ↗

Evi‐1 promotes para‐aortic splanchnopleural hematopoiesis through up‐regulation of GATA‐2 and repression of TGF‐b signalingSemantic proximity Read ↗

Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in LeukemogenesisSemantic proximity Read ↗

Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.Semantic proximity Read ↗

Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line.Semantic proximity Read ↗

EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2Semantic proximity Read ↗

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