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Article

Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26.

1 May 1992

Abstract excerpt

Retroviral activation of Evi-1 gene expression is one of the most common transforming events in murine myeloid leukemias. To evaluate the role of the EVI1 gene in human acute myelogenous leukemia (AML), leukemic blasts or cell lines from 116 patients were examined. In eight patients the EVI1 gene was expressed and all but one had cytogenetically detectable translocations of chromosome 3q26 where the EVI1 gene has...

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Identifiers

PMID: 1570317
DOI: 10.1073/pnas.89.9.3937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26.PMID 1570317Read ↗

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocationsSemantic proximity Read ↗

High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patientsSemantic proximity Read ↗

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Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26)Semantic proximity Read ↗

Three novel cytogenetically cryptic EVI1 rearrangements associated with increased EVI1 expression and poor prognosis identified in 27 acute myeloid leukemia casesSemantic proximity Read ↗

Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter.Semantic proximity Read ↗

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High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimatedSemantic proximity Read ↗

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EVI1 drives leukemogenesis through aberrant ERG activationSemantic proximity Read ↗

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