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Article

[The role of SF3B1 mutations in EVI1-rearranged myeloid neoplasms].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2023

Tanaka Atsushi

Abstract excerpt

In acute myeloid leukemia (AML), EVI1 rearrangement represented by inv(3)(q21q26) or t(3;3)(q21;q26) causes EVI1 overexpression via structural rearrangement of an enhancer, and confers poor prognosis. My colleagues and I performed a mutational analysis of EVI1-rearranged myeloid neoplasms and identified SF3B1, a core RNA splicing factor, as the most commonly co-mutated gene. Indeed, latent leukemia development in...

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Source

Identifiers

PMID: 37914237
DOI: 10.11406/rinketsu.64.1258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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