Article
Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence.
The Journal of general virology - 1 Mar 1991
MacLean A R, ul-Fareed M, Robertson L, Harland J, Brown S M
Abstract excerpt
Dideoxynucleotide sequence analysis of a spontaneously isolated deletion variant (1714) of Glasgow strain 17+ of herpes simplex virus type 1 (HSV-1) demonstrates that the deletion is 759 bp in length and is located within each copy of the BamHI s fragment (0 to 0.02 and 0.81 to 0.83 map units) of...
Topics
- Animals
- Autoradiography
- Base Sequence
- Blotting, Southern
- Brain
- Cell Line
- DNA, Viral
- Deoxyribonuclease BamHI
- Encephalitis
- Herpes Simplex
- Humans
- Kinetics
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Restriction Mapping