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Article

Abolition of the RL neurovirulence phenotype of herpes simplex virus type 2 strain HG52 does not require deletion of the DR1 element of the 'a' sequence.

The Journal of general virology - 1 Nov 1991

Harland J, Brown S M

Abstract excerpt

We have characterized a spontaneous variant of herpes simplex virus type 2 (HSV-2) strain HG52, 2616, which has 786 bp of both copies of RL deleted, but which retains 782 bp upstream of the 5' end of immediate early gene 1 and 463 bp downstream of the 'a' sequence. Variant 2616 is avirulent follo...

Topics

Animals
Chromosome Deletion
Genes, Viral
Mice
Mice, Inbred BALB C
Mutation
Phenotype
Repetitive Sequences, Nucleic Acid
Simplexvirus
Virulence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1658204
DOI: 10.1099/0022-1317-72-11-2777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1658204-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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