Abolition of the RL neurovirulence phenotype of herpes simplex virus type 2 strain HG52 does not require deletion of the DR1 element of the 'a' sequence.

Abstract excerpt

We have characterized a spontaneous variant of herpes simplex virus type 2 (HSV-2) strain HG52, 2616, which has 786 bp of both copies of RL deleted, but which retains 782 bp upstream of the 5' end of immediate early gene 1 and 463 bp downstream of the 'a' sequence. Variant 2616 is avirulent following intracerebral inoculation of BALB/c mice, thus showing in vivo characteristics similar to those of variant 2604,...

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