ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures.

doi:10.1128/JVI.68.1.48-55.1994

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Article

ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures.

Journal of virology - 1 Jan 1994

Bolovan C A, Sawtell N M, Thompson R L

Abstract excerpt

In a recent report, the neurovirulence of herpes simplex virus type 1 (HSV-1) was mapped to the ICP34.5 gene (J. Chou, E. R. Kern, R. J. Whitley, and B. Roizman, Science 250:1262-1266, 1990). In this report, specific mutations within ICP34.5 were constructed in HSV-1 strain 17syn+ to determine th...

Topics

Animals
Base Sequence
Cells, Cultured
Embryo, Mammalian
Eye
Herpesvirus 1, Human
Kinetics
Mice
Mice, Inbred C3H
Molecular Sequence Data
Mutation
Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Rabbits

Sequence Deletion

Terminator Regions, Genetic

Viral Proteins

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 8254758
DOI: 10.1128/JVI.68.1.48-55.1994
PMCID: PMC236262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8254758-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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