Article
The herpes simplex virus type 1 strain 17+ gamma 34.5 deletion mutant 1716 is avirulent in SCID mice.
The Journal of general virology - 1 Aug 1994
Valyi-Nagy T, Fareed M U, O'Keefe J S, Gesser R M, MacLean A R, Brown S M, Spivack J G, Fraser N W
Abstract excerpt
Laboratory animal models are important tools for the identification of avirulent herpes simplex virus type 1 (HSV-1) strains which have potential for use in humans as vaccine strains or gene therapy vectors. We have studied an HSV-1 17+ variant, 1716, that has a deletion in the gamma 34.5 gene an...
Topics
- Animals
- Central Nervous System
- Eye
- Ganglia, Spinal
- Genes, Viral
- Herpes Simplex
- Herpesvirus 1, Human
- In Situ Hybridization
- Mice
- Mice, SCID
- Mutation
- RNA, Messenger