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Article

The herpes simplex virus type 1 strain 17+ gamma 34.5 deletion mutant 1716 is avirulent in SCID mice.

The Journal of general virology - 1 Aug 1994

Valyi-Nagy T, Fareed M U, O'Keefe J S, Gesser R M, MacLean A R, Brown S M, Spivack J G, Fraser N W

Abstract excerpt

Laboratory animal models are important tools for the identification of avirulent herpes simplex virus type 1 (HSV-1) strains which have potential for use in humans as vaccine strains or gene therapy vectors. We have studied an HSV-1 17+ variant, 1716, that has a deletion in the gamma 34.5 gene and which replicates poorly in the footpads of mice and is unable to grow in the mouse central nervous system or dorsal...

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PMID: 8046409
DOI: 10.1099/0022-1317-75-8-2059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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