The US 9, 10, 11, and 12 genes of herpes simplex virus type 1 are of no importance for its neurovirulence and latency in mice.

doi:10.1006/viro.1993.1279

Back to search

Article

The US 9, 10, 11, and 12 genes of herpes simplex virus type 1 are of no importance for its neurovirulence and latency in mice.

Virology - 1 May 1993

Nishiyama Y, Kurachi R, Daikoku T, Umene K

Abstract excerpt

We have studied the pathogenic and latency/reactivation potential of a herpes simplex virus type 1 (HSV-1) variant (N38) which has a deletion of four genes, US9, US10, US11, and US12, in the short unique region of the HSV-1 genome. N38 was as pathogenic as the parental wild-type virus following i...

Topics

Animals
Brain
Cornea
Gene Deletion
Genes, Viral
Genetic Variation
Genome, Viral
Lethal Dose 50
Male
Mice
Mice, Inbred ICR
Organ Specificity
RNA-Binding Proteins
Simplexvirus
Viral Proteins
Virulence

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.