Article
Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland.
Oral oncology - 1 Sept 2008
Marques Yonara Maria Freire Soares, de Lima Marina de Deus Moura, de Melo Alves Sérgio de Melo, Soares Fernando Augusto, de Araújo Vera Cavalcanti, Pinto Décio dos Santos, Mantesso Andrea
Abstract excerpt
The p53 protein can be altered virtually in all human cancers. In the absence of p53 mutations, p53 inactivation is possible via complex formation with other proteins, such as Mdm2. Previous studies have shown an overexpression of Mdm2 and lack of p53 expression in pleomorphic adenomas. The pAkt protein is closely related to Mdm2, and has not been previously reported in salivary gland tumors. The aim of this...
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