Article
Assessment of CTNNB1 gene mutations and β-catenin immunoexpression in salivary gland pleomorphic adenomas and adenoid cystic carcinomas.
Virchows Archiv : an international journal of pathology - 1 Jun 2018
Cavalcante Roberta Barroso, Nonaka Cassiano Francisco Weege, Santos Hellen Bandeira de Pontes, Rabenhorst Silvia Helena Barem, Pereira Pinto Leão, de Souza Lélia Batista
Abstract excerpt
β-Catenin exerts multiple functions in several neoplasms, playing a major role in cell signaling and tumor progression. This study analyzed possible CTNNB1 mutations in salivary gland pleomorphic adenomas (PAs) and adenoid cystic carcinomas (ACCs), and determined possible differences in β-catenin immunoexpression in relation to these mutations, as well as histopathological aspects of these tumors. Twenty-four PAs...
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