Article
Immunohistochemical Mdm2 expression in minor salivary gland tumours and its relationship to p53 gene status.
Oral oncology - 1 Jan 2000
de Araújo V C, Martins M T, Leite K R, Gomez R S, de Araújo N S
Abstract excerpt
Mdm2 protein is a cellular regulator of p53 protein activity. Minor salivary gland tumours were investigated for immunohistochemical expression of Mdm2 protein and for p53 gene status. Formalin-fixed sections were submitted to monoclonal antibody anti-Mdm2 through use of the streptavidin-biotin method. Nuclear immunoreactivity was scored 1 (0-25% nuclei positive), 2 (26-50%), 3 (51-75%) and 4 (> 75%). The scores...
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