Article
TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas.
Journal of cellular physiology - 1 Jun 2006
Augello Claudia, Gregorio Valter, Bazan Viviana, Cammareri Patrizia, Agnese Valentina, Cascio Sandra, Corsale Simona, Calò Valentina, Gullo Arianna, Passantino Rita, Gargano Grazia, Bruno Loredana, Rinaldi Gaetana, Morello Vincenza, Gerbino Aldo, Tomasino Rosa Maria, Macaluso Marcella, Surmacz Eva, Russo Antonio
Abstract excerpt
The putative role of TP53 and p16(INK4A) tumor suppressor genes and Ras oncogenes in the development and progression of salivary gland neoplasias was studied in 28 cases of pleomorphic adenomas (PA), 4 cases of cystic adenocarcinomas, and 1 case of carcinoma ex-PA. Genetic and epigenetic alterations in the above genes were analyzed by Polymerase Chain Reaction/Single Strand Conformational Polymorphism (PCR/SSCP)...
Topics
- Adenoma
- Base Sequence
- Cell Transformation, Neoplastic
- Cyclin-Dependent Kinase Inhibitor p16
- Disease Progression
- Epigenesis, Genetic
- Genotype
- Humans
- Methylation