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Article

Neutrophils are resistant to Yersinia YopJ/P-induced apoptosis and are protected from ROS-mediated cell death by the type III secretion system.

PloS one - 18 Feb 2010

Spinner Justin L, Seo Keun Seok, O'Loughlin Jason L, Cundiff Jennifer A, Minnich Scott A, Bohach Gregory A, Kobayashi Scott D

Abstract excerpt

BACKGROUND: The human innate immune system relies on the coordinated activity of macrophages and polymorphonuclear leukocytes (neutrophils or PMNs) for defense against bacterial pathogens. Yersinia spp. subvert the innate immune response to cause disease in humans. In particular, the Yersinia outer protein YopJ (Y. pestis and Y. pseudotuberculosis) and YopP (Y. enterocolitica) rapidly induce apoptosis in murine...

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PMID: 20174624
DOI: 10.1371/journal.pone.0009279
PMCID: PMC2823771

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Neutrophils are resistant to Yersinia YopJ/P-induced apoptosis and are protected from ROS-mediated cell death by the type III secretion system.PMID 20174624Read ↗

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