Article
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.
Oncogene - 6 Sept 2001
Falck J, Lukas C, Protopopova M, Lukas J, Selivanova G, Bartek J
Abstract excerpt
Recent evidence identified a genetic and functional link between Chk2 kinase and p53 as a candidate genome integrity checkpoint and a tumour suppressor pathway. Here we report that in human cells, Chk2 and p53 form protein-protein complexes whose abundance increased upon DNA damage, and whose formation was abrogated through cancer associated mutations in the FHA domain of Chk2, or mutations in the tetramerization...
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