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Article

Targeted knockout of BRG1 potentiates lung cancer development.

Cancer research - 15 May 2008

Glaros Selina, Cirrincione Georgina M, Palanca Ariel, Metzger Daniel, Reisman David

Abstract excerpt

Brahma-related gene 1 (BRG1) is a catalytic subunit of the switch in mating type/sucrose nonfermentation complex and plays an important role in cancer development. Mouse homozygous knockout experiments testing the role of BRG1 in tumorigenesis have been hampered because BRG1 inactivation is embryonic lethal. To bypass this constraint, we developed a lung-specific conditional knockout of BRG1 and examined the...

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PMID: 18483251
DOI: 10.1158/0008-5472.CAN-07-6652

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Targeted knockout of BRG1 potentiates lung cancer development.PMID 18483251Read ↗

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Characterization of a Brg1 hypomorphic allele demonstrates that genetic and biochemical activity are tightly correlated.Semantic proximity Read ↗

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation.Semantic proximity Read ↗

Brahma-related gene 1 regulates the proliferation of alveolar type II epithelial cells via the JAK1/2-PI3K/AKT signaling pathwaySemantic proximity Read ↗

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.Semantic proximity Read ↗

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A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.Semantic proximity Read ↗

Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth ArrestSemantic proximity Read ↗

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