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Article

Mechanism of BRG1 silencing in primary cancers.

Oncotarget - 30 Aug 2016

Marquez-Vilendrer Stefanie B, Thompson Kenneth, Lu Li, Reisman David

Abstract excerpt

BRG1 (SMARCA4) is a documented tumor suppressor and a key subunit of the SWI/SNF chromatin remodeling complex that is silenced in many cancer types. Studies have shown that BRG1 is mutated in cancer-derived cell lines, which led to the assertion that BRG1 is also mutated in primary human tumors. However, the sequencing of BRG1-deficient tumors has revealed a paucity of mutations; hence, the cause of BRG1...

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Source

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Identifiers

PMID: 27486753
DOI: 10.18632/oncotarget.10593
PMCID: PMC5302903

Genes

SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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