Article

Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets

2022-03-30

Abstract excerpt

Exogenous glucocorticoids are widely used in the clinic for the treatment of inflammatory disorders and auto-immune diseases. Unfortunately, their use is hampered by many side effects and therapy resistance. Efforts to find more selective glucocorticoid receptor (GR) agonists and modulators (called SEGRAMs) that are able to separate anti-inflammatory effects via gene repression from metabolic effects via gene acti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45864c40-a9ee-5de7-933d-b5be2b8eb129
DOI: 10.1101/2022.03.29.486227

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targetsDOI 10.1101/2022.03.29.486227Read

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid ReceptorSemantic proximity Read

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious DiseasesSemantic proximity Read

Dissociated non-steroidal glucocorticoid receptor modulators: an update on new compoundsSemantic proximity Read

The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid SensitivitySemantic proximity Read

Discovery of Compound A - a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activitySemantic proximity Read

Glucocorticoid receptors: finding the middle groundSemantic proximity Read

Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics eraSemantic proximity Read

A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiologySemantic proximity Read

Selective Glucocorticoid Receptor modulators.Semantic proximity Read

Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene?Semantic proximity Read

Glucocorticoid receptor phosphorylation differentially affects target gene expression.Semantic proximity Read

New Insights in Glucocorticoid Receptor Signaling—More Than Just a Ligand-Binding ReceptorSemantic proximity Read