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Article

Biased regulation of glucocorticoid receptors signaling

14 Jul 2023

Abstract excerpt

Glucocorticoids (GCs), steroid hormones that depend on glucocorticoid receptor (GR) binding for their action, are essential for regulating numerous homeostatic functions in the body.GR signals are biased, that is, GR signals are various in different tissue cells, disease states and ligands. This biased regulation of GR signaling appears to depend on ligand-induced metameric regulation, protein post-translational...

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PMID: 37454592
DOI: 10.1016/j.biopha.2023.115145

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