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Article

RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity.

Molecular and cellular biology - 1 Jun 2013

Druker Jimena, Liberman Ana C, Antunica-Noguerol María, Gerez Juan, Paez-Pereda Marcelo, Rein Theo, Iñiguez-Lluhí Jorge A, Holsboer Florian, Arzt Eduardo

Abstract excerpt

Glucocorticoid receptor (GR) activity is modulated by posttranslational modifications, including phosphorylation, ubiquitination, and SUMOylation. The GR has three SUMOylation sites: lysine 297 (K297) and K313 in the N-terminal domain (NTD) and K721 within the ligand-binding domain. SUMOylation of the NTD sites mediates the negative effect of the synergy control motifs of GR on promoters with closely spaced GR...

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Identifiers

PMID: 23508108
DOI: 10.1128/MCB.01470-12
PMCID: PMC3648064

Genes

GRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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