β‐Cell gene expression stress signatures in types 1 and 2 diabetes

Abstract excerpt

Diabetes mellitus (DM) is a chronic metabolic disorder that occurs when pancreatic β-cells can no longer produce enough insulin to maintain normal blood glucose levels. DM presently affects 10.5% of the world adult population. While T1D is a disease of “mistaken identity,” where the immune system attacks and destroys pancreatic β-cells in the context of islet inflammation (insulitis),1 T2D is associated with...

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