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G9a Histone Methyltransferase Contributes to Imprinting in the Mouse Placenta

27 Nov 2007

Abstract excerpt

Whereas DNA methylation is essential for genomic imprinting, the importance of histone methylation in the allelic expression of imprinted genes is unclear. Imprinting control regions (ICRs), however, are marked by histone H3-K9 methylation on their DNA-methylated allele. In the placenta, the paternal silencing along the Kcnq1 domain on distal chromosome 7 also correlates with the presence of H3-K9 methylation,...

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PMID: 18039842
DOI: 10.1128/mcb.01111-07

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G9a Histone Methyltransferase Contributes to Imprinting in the Mouse PlacentaPMID 18039842Read ↗

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