Article
Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes.
Human molecular genetics - 15 Aug 2011
Nakabayashi Kazuhiko, Trujillo Alex Martin, Tayama Chiharu, Camprubi Cristina, Yoshida Wataru, Lapunzina Pablo, Sanchez Aurora, Soejima Hidenobu, Aburatani Hiroyuki, Nagae Genta, Ogata Tsutomu, Hata Kenichiro, Monk David
Abstract excerpt
Nuclear transfer experiments undertaken in the mid-80's revealed that both maternal and paternal genomes are necessary for normal development. This is due to genomic imprinting, an epigenetic mechanism that results in parent-of-origin monoallelic expression of genes regulated by germline-derived allelic methylation. To date, ∼100 imprinted transcripts have been identified in mouse, with approximately two-thirds...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.