Article
Molecular and genetic analysis of condensin function in vertebrate cells.
Molecular biology of the cell - 1 Jul 2008
Hudson Damien F, Ohta Shinya, Freisinger Tina, Macisaac Fiona, Sennels Lau, Alves Flavia, Lai Fan, Kerr Alastair, Rappsilber Juri, Earnshaw William C
Abstract excerpt
We engineered mutants into residues of SMC2 to dissect the role of ATPase function in the condensin complex. These residues are predicted to be involved in ATP binding or hydrolysis and in the Q-loop, which is thought to act as a mediator of conformational changes induced by substrate binding. All the engineered ATPase mutations resulted in lethality when introduced into SMC2 null cells. We found that ATP...
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